Tay-Sachs, Sandhoff and GM-1
It is especially difficult to know what to expect with Juvenile Tay-Sachs, Sandhoff and GM-1 because the severity of the disease can vary greatly. Generally the younger the symptoms start the faster the disease will progress. A child whose development shows in early childhood will have a faster disease course than a child whose development shows in later childhood.
Generally the first signs of Juvenile Tay-Sachs, Sandhoff and GM-1 are slowed development and muscle weakness.
Living with the Disease
Seizures, swallowing difficulties and excessive secretions become issues as the disease progresses.
Eventually the child becomes dependent for all day-to-day functions, may require a feeding tube and may experience seizure activity.