Yes. Tay-Sachs disease enzyme analysis is very sensitive but can be affected by pregnancy status, medications, and transport temperature. DNA mutation analysis may help clarify whether an individual is truly a carrier for Tay-Sachs disease. Typically DNA and enzyme testing are performed at the same time to allow for optimal interpretation of results.
A genetics professional can help you to understand what this result means for you and your family. Visit Genetic Counseling to get in contact with a provider near you.