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Tay-Sachs, Canavan, GM1 and Sandhoff diseases

Canavan Symptoms

First signs

A baby with Canavan may appear normal at birth and typically develops normally for several months. Sometimes symptoms are noticeable at birth. As development slows, parents may notice a reduction in vision and tracking.

Gradual Loss of skills

Children with Canavan gradually regress, losing skills one by one, and eventually are unable to crawl, turn over, sit or reach out.  Other symptoms include loss of coordination, progressive inability to swallow and difficulty breathing.

By Age 3 and beyond

By age 3, children progressively lose muscle tone and function. Some children experience recurrent seizures. Despite their inability to communicate by traditional means many parents believe their child understands their surroundings and can speak volumes with their eyes.

Canavan Review Article

Canavan disease was first described in 1931, and this review traces the progress made in the past 8 decades to understand the disease by enumerating current hypotheses and ongoing palliative measures to alleviate patient symptoms in the context of the latest advances in the field.

Read article: Making the White Matter Matters: Progress in Understanding Canavan’s Disease and Therapeutic Interventions Through Eight Decades, Seemin S. Ahmed • Guangping Gao